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Kaempferol, a Tea Flavonol, Effect on Interleukin-2 Signal Transduction of Human T Cell Leukemia

JARQ : Japan Agricultural Research Quarterly
ISSN
00213551
書誌レコードID(総合目録DB)
AA0068709X
本文フルテキスト

CCRF-CEM and Jurkat E6-1, human T cell leukemia, produced interleukin (IL)-2 stimulated with phorbol myristate acetate (PMA) and pokeweed mitogen (PWM). IL-2 cytokine production and mRNA expression of CCRF-CEM were increased by treatment with kaempferol, a tea (Camellia sinensis L.) flavonol, while those of Jurkat E6-1 were decreased by kaempferol treatment. We therefore investigated the nuclear factor expression of activated T cell (NFAT), a critical regulator of IL-2 gene transcription during T cell activation. In CCRF-CEM, NFAT induction of cytoplasmic extract and NFAT translocation to the nucleus were increased by kaempferol, demonstrating that kaempferol might affect the upstream cascade of T cell signaling. However, in Jurkat E6-1, NFAT induction of cytoplasmic extract was normal, but NFAT translocation to the nucleus was decreased by kaempferol treatment. In this report, it is demonstrated that kaempferol has different effects in the T cell signaling cascade.

刊行年月2005-07-01
作成者ASAI KazumiMORIWAKI SawakoMAEDA-YAMAMOTO Mari
著者キーワード

cytokine

tea (Camellia sinensis L.)

NFAT (nuclear factor expression of activated T cell)

公開者Japan International Research Center for Agricultural Sciences
データ作成日2005-07-01
国立情報学研究所メタデータ主題語彙集(資源タイプ)Journal Article
39
3
開始ページ175
終了ページ179
DOI10.6090/jarq.39.175
権利Japan International Research Center for Agricultural Sciences
言語eng