Nodal Pleomorphic B Cell Lymphoma at the Earliest Stage of Tumor Development in a Cow

JARQ : Japan Agricultural Research Quarterly
ISSN 00213551
書誌レコードID(総合目録DB) AA0068709X

Pleomorphic B cell lymphoma was detected in a small number of lymph nodes in an 8-year-old Holstein cow with persistent lymphocytosis associated with bovine leukemia virus (BLV). Necropsy showed enlargement of the left superficial inguinal and right deep inguinal lymph nodes. Large numbers of BLV copies were detected by real-time polymerase chain reaction analysis in the enlarged nodes, whereas little BLV was found in normal-sized lymph nodes. Histologically, the enlarged lymph nodes were occupied by diffusely growing pleomorphic cells. In a few other lymph nodes, in contrast, extensive areas of neoplastic mantle cells showing a transition to more malignant pleomorphic cells were observed. These virological and histological findings indicate that large numbers of viral copies may be closely related to transformation from neoplastic mantle cells to pleomorphic lymphoma cells. The current study supports the view that nodal pleomorphic B cell lymphoma is of mantle cell origin.

作成者 Yuichiro SOCHI Hironori TAKAMORI Hidetoshi SATO Takashi NUMABE Akiyo HAGIWARA Yoshiharu ISHIKAWA Koichi KADOTA
著者キーワード Bovine leukemia virus lymphoma in situ mantle zone neoplastic transformation persistent lymphocytosis
公開者 Japan International Research Center for Agricultural Sciences
国立情報学研究所メタデータ主題語彙集(資源タイプ) Journal Article
開始ページ 353
終了ページ 358
DOI 10.6090/jarq.52.353
言語 eng