Hypergranular γδ T-Cell Lymphoma in a Heifer

JARQ : Japan Agricultural Research Quarterly
ISSN 00213551
書誌レコードID(総合目録DB) AA0068709X
41-01-11.pdf1.39 MB

Lymphoma with large granular lymphocyte (LGL) morphology in a heifer is described. The most noticeable macroscopic finding was neoplastic involvement of the skin, mucosae of the alimentary tract, urinary bladder, and uterus. Histologically, lymphoma cells with large numbers of fine eosinophilic granules predominated in the neoplastic tissue, and the granules were positive for perforin. Surface CD3, CD5 or WC1 was expressed by some neoplastic cells. In addition to the epitheliotropism that is a feature of ordinary γδ T-cell lymphoma, the neoplastic cells showed angiodestruction and erythrophagocytosis. These phenomena were thought to result from marked activation of neoplastic γδ T-cells. The present lymphoma was distinct from the previously reported bovine NK-like T-cell lymphoma in its tissue distribution, cytomorphology, cytochemistry, and immunophenotype. Since this lymphoma was regarded as a cytologic variant of γδ T-cell lymphoma, the term hypergranular γδ T-cell lymphoma seemed to be more appropriate than γδ T-cell LGL lymphoma.

作成者 NAITOU Kazumi ISHIKAWA Yoshiharu KADOTA Koichi

angiodestructive growth pattern

large granular lymphocyte lymphoma



公開者 Japan International Research Center for Agricultural Sciences
国立情報学研究所メタデータ主題語彙集(資源タイプ) Journal Article
開始ページ 79
終了ページ 83
DOI 10.6090/jarq.41.79
権利 Japan International Research Center for Agricultural Sciences
言語 eng