国立研究開発法人 国際農林水産業研究センター | JIRCAS

Immunomodulatory Effects of <i>Lactococcus lactis </i>Strains

JARQ : Japan Agricultural Research Quarterly
ISSN
00213551
書誌レコードID(総合目録DB)
AA0068709X
本文フルテキスト

Strains of Lactococcus lactis are present in various natural environment or fermented products, and have been used as starters. In this review, we firstly discuss the immunomodulatory effects of Lactococcus strains from the perspective of their strain-specificity. Forty-six different Lactococcus strains were investigated for their ability to induce cytokine production in the murine macrophage-like cell line, J774.1. Strain-specificity and heat stability related to the ability of Lactococcus cells to induce interleukin (IL)-6, IL-12 and TNF-α, and induce cell necrosis or apoptosis were discussed. Secondly, to examine the immunomodulatory effects of Lactococcus cells in vivo, the effects of oral administration of four strains were investigated for their ability to regulate IgE production in ovalbumin-sensitized mice. Among the four strains, only L. lactis strain C59 showed a significant reduction in the total IgE antibody levels in serum. This suppressive effect on IgE antibody production was lost when strain C59 was heat-killed. Experiments using splenocytes of mice administered with live strain C59 indicated that the suppression of IgE antibody production by live strain C59 was due to the suppression of IL-4 production. The strain-specific immunomodulatory effects of Lactococcus strains are discussed.

刊行年月2013-07-01
作成者SUZUKI ChiseKIMOTO-NIRA HiromiKOBAYASHI MihoNOMURA MasaruSASAKI KeisukeYOSHIDA AyakoAOKI ReijiMIZUMACHI Koko
著者キーワード

apoptosis

IgE antibody

interleukin

lactic acid bacteria

macrophage

公開者Japan International Research Center for Agricultural Sciences
データ作成日2013-07-01
国立情報学研究所メタデータ主題語彙集(資源タイプ)Journal Article
47
3
開始ページ249
終了ページ255
DOI10.6090/jarq.47.249
権利Japan International Research Center for Agricultural Sciences
言語eng