The regionalization, including three regions and ten sub-regions, with respect to cropping systems of soybeans is presented. The cropping systems and related soybean cultivars of the Chang-Jian Valley. Southeastern, Mid-southern, Southwestern, and Tropical sub-regions in the Southern Multiple Cropping, Multiple Planting Region are described. Among them, the Chang-Jian Valley Sub-region is the most important area for soybeans in the Southern Region. There is a potential to raise the soybean production in this region since it is possible to increase both the acreage and unit acreage yield. The approaches are discussed.