国立研究開発法人 国際農林水産業研究センター | JIRCAS

ldentification of Antimutagenic Substances (Ames Test) from <i>Boesenbergia pandurata</i> Schl. (Fingerroot) and <i>Languas galanga</i> (Galanga)

JIRCAS Journal
ISSN
13407686
書誌レコードID(総合目録DB)
AA11030483
本文フルテキスト

Methanolic extracts of Boesenbergia pandurata Schl. (fingerroot) and Languas galanga (galanga) that are spices commonly consumed in Thailand, showed a potent inhibitory activity on the mutagenesis induced by 3-amino-1,4-dimethyl-5H-pyrido [ 4,3-b ] indole (Trp-P-1) in Salmonella typhimurium TA98. Then the isolation and characterization of the antimutagenic compounds from both plants was carried out using reversed phase column chromatography. Six active compounds (FR1, FR2, FR3, FR4, FR5 and FR6) from fingerroot and two active compounds (G1 and G2) from galanga were isolated. The physico-chemical properties of these compounds were determined by liquid chromatography-mass spectrometry and UV-absorption spectrometry. FR1 and FR3 were identified as chalcone derivatives, and, FR2 and FR4 were identified as flavanone derivatives. FR5 and FR6 could not be identified due to insufficient information. G1 and G2 were estimated to be phenylpropanoid derivatives. The six isolated compounds from fingerroot exhibited a more pronounced antimutagenic effect than two compounds from galanga, at the concentration of 25 μg/plate. The antimutagenic activity of all the isolated compounds was fairly stable upon heat treatment and persisted after heating at 105℃ for 15 min .

刊行年月1999-03-01
作成者Gassinee TRAKOONTIVAKORNKazuhiko NAKAHARAHiroshi SHlNMOTOTojiro TSUSHIDA
著者キーワードantimutagenicityBoesenbergia Pandurata Schl.Languas galangaThai spicesAmes test
公開者Japan International Research Center for Agricultural Sciences
データ作成日1999-03-01
国立情報学研究所メタデータ主題語彙集(資源タイプ)Journal Article
7
開始ページ105
終了ページ116
権利Japan International Research Center for Agricultural Sciences
言語eng