Disulfide Proteomics: Current Status in Thioredoxin Biochemistry and Industrial Research

JARQ : Japan Agricultural Research Quarterly
ISSN 00213551
書誌レコードID(総合目録DB) AA0068709X
本文フルテキスト
46-04-01.pdf604.98 KB

Redox regulation is a central control element across a broad spectrum of biology. Thioredoxin (Trx), a widely distributed disulfide enzyme, participates in the control of numerous target proteins, thus playing a key role in regulatory processes. Identification of Trx′s targets will therefore aid the elucidation of redox biology. Two recently developed procedures, one based on thiol-specific probes and the other on affinity trapping, have facilitated the labeling or isolation of potential Trx targets that were later identified with proteomic approaches. Accordingly, the number of identified targets in plants has increased to 400. This review describes recent advances in proteomic strategies that are effectively overcoming challenging problems such as the evaluation of target authenticity. Also presented are two industrial research areas, food processing and medical investigation, in which disulfide-related proteomic studies beyond plant biology are underway.

刊行年月日
作成者 KAWAKAMI Takao YANO Hiroyuki
著者キーワード

biomarker

redox regulation

公開者 Japan International Research Center for Agricultural Sciences
データ作成日
国立情報学研究所メタデータ主題語彙集(資源タイプ) Journal Article
46
4
開始ページ 277
終了ページ 285
DOI 10.6090/jarq.46.277
権利 Japan International Research Center for Agricultural Sciences
言語 eng