国立研究開発法人 国際農林水産業研究センター | JIRCAS

Cell-mediated Immunity to Influenza Virus Infections: From the Perspective to the Vaccine Development against Highly Pathogenic Avian Influenza

JARQ : Japan Agricultural Research Quarterly
ISSN
00213551
書誌レコードID(総合目録DB)
AA0068709X
本文フルテキスト

Inactivated vaccines have been incorporated in the control strategies for highly pathogenic avian influenza (HPAI) in several countries. However, these conventional vaccines confer protective immunity in the hemagglutinin (HA) subtype-specific manner and inevitably promote antigenic drifts in HA of target viruses. Therefore, the efficacy of the conventional vaccines needs to be evaluated occasionally to assure that they still provide immunity against emerging or circulating field virus strains. To cover these pitfalls, novel vaccine strategies which target conserved viral antigens are currently being investigated. We hypothesize that such vaccines can be developed by utilizing cytotoxic CD8+ T cell-mediated immunity. However, we do not fully understand the mechanisms of the generation, maintenance and recall of cell-mediated immunity to influenza virus infections. Here we briefly review the current knowledge of cell-mediated immunity to influenza virus infections based on the studies using mouse models and discuss the future application of this immunological arm to the vaccines against HPAI in poultry.

刊行年月2008-10-01
作成者HIKONO HirokazuMASE MasajiWATANABE SatokoOGAWA YohsukeMUNETA YoshihiroKUBOTA TakayukiSHIMOJI Yoshihiro
著者キーワード

CD8+ T cells

recall response

T-cell memory

公開者Japan International Research Center for Agricultural Sciences
データ作成日2008-10-01
国立情報学研究所メタデータ主題語彙集(資源タイプ)Journal Article
42
4
開始ページ245
終了ページ249
DOI10.6090/jarq.42.245
権利Japan International Research Center for Agricultural Sciences
言語eng