国立研究開発法人 国際農林水産業研究センター | JIRCAS

Sesamin, a Sesame Lignan, as a Potent Serum Lipid-Lowering Food Component

JARQ : Japan Agricultural Research Quarterly
ISSN
00213551
書誌レコードID(総合目録DB)
AA0068709X
本文フルテキスト

Effect of sesamin, a sesame lignan, on the hepatic fatty acid metabolism was examined in the rat. Increase of the dietary level of sesamin progressively increased the mitochondrial and peroxisomal fatty acid oxidation rate. Mitochondrial activity almost doubled in rats fed a 0.5% sesamin diet. Peroxisomal activity became more than 10 times higher in rats fed a 0.5% sesamin diet, compared to those fed a sesamin-free diet. Dietary sesamin also markedly increased the hepatic activity and mRNA levels of various fatty acid oxidation enzymes. In contrast, dietary sesamin decreased the hepatic activity and mRNA abundance of lipogenic enzymes. This was associated with the down-regulation of sterol regulatory element-binding protein-1, a transcriptional factor that regulates the lipogenic enzyme gene expression. Dietary sesamin significantly decreased the triacylglycerol secretion accompanying the increase in ketone body production by the perfused rat liver. It is apparent that sesamin affects the fatty acid metabolism and lipoprotein production in the liver, and hence lowers the serum lipid levels. We also developed several sesame lines with seeds containing sesamin and sesamolin at twice the concentration of conventional cultivars. Compared to a conventional cultivar, these lignan-rich sesame seeds increased the hepatic fatty acid oxidation rate and lowered the serum triacylglycerol level in the rat. Therefore, it is considered that enrichment of the lignans potentiates the characteristics of sesame in improving human health.

刊行年月2003-07-01
作成者IDE TakashiKUSHIRO MasayoTAKAHASHI YokoSHINOHARA KazukiFUKUDA NobuhiroSIRATO-YASUMOTO Satoko
著者キーワード

sesame

fatty acid oxidation

fatty acid synthesis

lipoprotein production

rat

公開者Japan International Research Center for Agricultural Sciences
データ作成日2003-07-01
国立情報学研究所メタデータ主題語彙集(資源タイプ)Journal Article
37
3
開始ページ151
終了ページ158
DOI10.6090/jarq.37.151
権利Japan International Research Center for Agricultural Sciences
言語eng