Isoflavone Content and Anti-acetylcholinesterase Activity in Commercial Douchi (a Traditional Chinese Salt-fermented Soybean Food)

Japan Agricultural Research Quarterly
ISSN 00213551
NII recode ID (NCID) AA0068709X
Full text
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The concentration and distribution of isoflavones in 19 representative commercial douchi products and their acetylcholinesterase (AChE) inhibitory activity were investigated in this study. Isoflavone aglycones are the predominant isoflavone forms in Chinese commercial douchi samples. The total content of isoflavones in douchi extracts were observed from 24 to 1,471 μg/g (dry matter). Results indicated that Aspergillus-type douchi had more isofiavone aglycones content than that of Mucor-type and Bacillus-type douchi. Nineteen samples also showed various extents of AChE inhibitory activity. The IC50 value of AChE inhibitory activities of douchi extracts ranged from 0.040 to 2.319 mg/mL. Aspergillus-type douchi extracts exhibited significantly higher AChE inhibitory activity than that of Mucor-type and Bacillus-type douchi. Some brands of douchi which have low contents of isofiavone aglycones showed much lower inhibitory activity. However, high inhibitory activities did not mean high isoflavone content, maybe some other substances contributed to the inhibition which should be further studied.

Date of issued
Creator LIU Yaqiong WANG Lijun CHENG Yongqiang SAITO Masayoshi YAMAKI Kohji QIAO Zhihong LI Lite
Subject

Alzheimer's disease

fermented food

Publisher Japan International Research Center for Agricultural Sciences
Available Online
NII resource type vocabulary Journal Article
Volume 43
Issue 4
spage 301
epage 307
DOI 10.6090/jarq.43.301
Rights Japan International Research Center for Agricultural Sciences
Language eng

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