Sex and Breed Differences in the Constitutive Gene Expression of Hepatic Drug Metabolizing Enzymes in Meishan and Landrace Pigs: Testosterone-Mediated Differences

Japan Agricultural Research Quarterly
ISSN 00213551
NII recode ID (NCID) AA0068709X
Full text
Drug metabolizing enzymes (DMEs) that exist primarily in the liver are one of the critical factors determining the susceptibility of animals and humans to xenobiotics such as drugs, and also metabolize steroid hormones and other endogenous compounds. Although sex and/or species differences in the constitutive gene expression levels of hepatic DMEs have been reported to date, the causes of such differences have yet to be completely explained. The DME genes of pigs have recently been identified. Because pigs are valuable animals for human pharmacological and toxicological studies, research on the gene expression of DMEs in pigs is being promoted. We have found sex and/or breed differences in the constitutive gene expression of hepatic DMEs, including cytochrome P450s, sulfotransferases, and UDP-glucuronosyltransferases, in Meishan and Landrace pigs. We propose that physiological serum testosterone level is a critical host factor producing these differences. This review discusses the testosterone-mediated gene expression of hepatic DMEs.
Date of issued
Creator Misaki KOJIMA
Subject

androgen

cytochrome P450s

liver

sulfotransferases

UDP- glucuronosyltransferases

Publisher Japan International Research Center for Agricultural Sciences
Received Date 2018-02-26
Accepted Date 2019-05-29
Volume 54
Issue 1
spage 7
epage 12
DOI 10.6090/jarq.54.7
Language eng

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