国立研究開発法人 国際農林水産業研究センター | JIRCAS

Molecular Biology for Genetic Deficiencies of Complement Components in Rabbits : C8α-γDeficiency and C3 Hypocomplementemia

JARQ : Japan Agricultural Research Quarterly
ISSN
00213551
書誌レコードID(総合目録DB)
AA0068709X
本文フルテキスト

The complement system is composed of approximately 20 plasma proteins and constitutes a major humoral defense and clearance system in the bloodstream. New complement deficiencies, i.e. C8α-γ deficiency (C8α-γD) and C3 hypocomplementemia (C3-hypo), were identified in rabbits. The C8α-γD and C3-hypo were transmitted as a simple autosomal recessive and condominant trait, respectively. The physiological characteristics and molecular bases for C8α-γD and C3-hypo were identified as follows: C8α-γD is characterized by dwarfism (non-pituitary), small litter size, small thymus, a low survival rate, severely reduced serum bactericidal activity and enhanced delayed-type hypersensitivity (DTH), and normal expression of α and γ genes, but abnormal co-translational processing of C8α gene (a mutation of the exon/intron junction of the C8α gene). C3-hypo is characterized by approximately 10% of normal serum C3 levels, a low survival rate, reduced serum bactericidal activity, suppressed DTH, and low levels of liver C3 mRNA (pretranslational defect), and C3 phenotypes are dependent on RFLPs of the C3 gene.

刊行年月1992-07-01
作成者Masanori KOMATSU
データ作成日1992-07-01
国立情報学研究所メタデータ主題語彙集(資源タイプ)Journal Article
26
1
開始ページ48
終了ページ54
言語eng