The aim of this review was to give an overview regarding key points of potato germplasm enhancement associated with the International Potato Center and its global research-for-development partners including feedback from technology and germplasm recipients. Highlights were addressed on the participation by Japanese scholars to CIP. Also, specific impacts were raised on the Japanese research contribution on potato research for technology application and development for the partner countries by co-working with key Japanese organizations. Special reference was made to research on genetic underpinnings and technology development for enhancing the introgression and incorporation of traits that were not available in the primary potato breeding pools. The use of genetic engineering was also judged and in particular for its potential to address global uses. Future outlook was also provided for hinting Japanese participation to the international agriculture.